In Adult, I would particularly love a funny/satirical horror, a humorous, over-the-top mystery/thriller, or a locked room mystery in a spec fic setting.
I'm NOT typically the right fit for hist fic, military, police procedurals, high fantasy/sci-fi, dystopian, or literary fic.
I tend toward upper MG, and love fantasy and contemporary narratives, but voice is the most important element for me in this age category. I want funny/quirky/snarky MG voices, something really strong that hooks you in immediately.